The Longevity Supplement Reference — Every Buying Guide in One Place
PureLongevity · Supplement Reference
The Longevity Supplement Reference
Every longevity supplement we've covered — buying guides, dose-response frameworks, brand audits, and the editorial picks we actually run. Organized by category for fast navigation.
How to use this page
The longevity supplement market is noisy. Most marketing copy emphasizes "clinical grade" or "patented" without addressing the actual question: at what dose, for which adult, with what biomarker outcome? This reference page consolidates our buying guides, dose-response frameworks, and editorial picks across the 7 most-researched longevity supplement categories.
If you're new to the longevity supplement protocol, start with Bryan Johnson Blueprint Decoded for the tier-by-tier framework. If you're optimizing a specific category, jump directly to that section below.
Category
Editorial pick
NAD+ precursors (NMN, NR)
Thorne NiaCel 400
Methyl donors (TMG)
Thorne TMG
Methylated B-vitamins
Thorne Methyl-Guard Plus
Magnesium (sleep)
Thorne Magnesium Bisglycinate
Omega-3 / Fish Oil
Thorne Super EPA Pro
Vitamin D + K2
Thorne Vitamin D/K2 Liquid
CoQ10
Thorne CoQ10
Probiotics
Thorne FloraMend Prime
NAD+ precursors — NMN & NR
NAD+ levels decline ~50% between ages 30 and 60. Restoring NAD+ via supplementation is one of the most-studied longevity interventions. NMN and NR are the two precursors with substantial clinical trial data. Most consumer products are sub-therapeutic — dose matters more than brand.
30% of adults carry MTHFR variants that impair methylation. Standard folic acid/cyanocobalamin doesn't bypass the variant. Methylated forms (5-MTHF, methylcobalamin, P5P) do. Critical for adults on high-dose NAD+ precursors (which consume methyl groups).
