Blood Markers & Biological Age — What to Actually Test
Biological age is measurable. The panels Attia, Means, and Dayspring actually run.
Biological age — measured via blood markers, epigenetic clocks, or composite indices — is the operational target of every serious longevity protocol. The standard annual physical doesn't measure it. The standard lipid panel doesn't measure it. What does measure it is a specific set of biomarkers that the longevity-focused clinicians (Attia, Means, Dayspring, Bhatt, Boz) have converged on over the past decade.
The high-leverage panel: apoB (not LDL-C), Lp(a) once in your life, hs-CRP, homocysteine, fasting insulin, HOMA-IR, HbA1c, the Omega-3 Index, 25-hydroxyvitamin D, ferritin, ALT, GGT, full thyroid panel including T3 and T4, sex hormones with appropriate age framing, and IGF-1. The optional layer: comprehensive epigenetic age clock (Horvath, GrimAge, PhenoAge), advanced lipid sub-fractionation, continuous glucose monitoring for 14+ day windows, and the inflammation panel.
The reference ranges most clinical labs use are designed for "not yet sick." The longevity-relevant optimal ranges are tighter. The Decode Your Biology guide covers the exact thresholds.
Research Library — full deep-dives on this topic
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10 Longevity Blood Markers Your Doctor Probably Isn't Running
apoB, Lp(a), hs-CRP, homocysteine, fasting insulin, Omega-3 Index, ferritin — and the optimal-range thresholds for each. -
The Multivitamin Myth: Why 27 Years of RCTs Show No Lifespan Benefit
Why you test first, then target the actual deficiency — not the other way around. -
The Longevity Wearables Stack: CGM, HRV, and the Numbers That Matter
Continuous data layered on top of the quarterly blood panel.
The supplements built on this research
Decode Your Biology: Blood Markers & Biological Age Guide →
The full panel, the optimal ranges, the retest cadence, and the targeted-intervention decision tree.
The Longevity Wearables Stack →
Oura, WHOOP, Apple Watch, Garmin, and the CGM — the daily data layer that the quarterly blood panel sits on top of.
Join the readers tracking what the longevity researchers actually do.
Weekly research feed — what changed, what replicated, what the labs are publishing right now.
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The working researchers and clinicians to follow on biomarkers are Peter Attia (Early Medical), Casey Means (Levels), Tom Dayspring (lipidology), and Steve Horvath (UCLA, epigenetic clocks). For the full biomarker panel + optimal ranges + intervention decision tree see Decode Your Biology.
First time here? Read who this is for — what we believe, what we don't, and whether the protocol matches how you actually want to age.